Silymarin Based Complexes - a mini
Review
Gertrud-Alexandra
PALTINEAN[1],
Gheorghe TOMOAIA[2],3, Sorin riga1,[3], Aurora
MOCANU1, Maria TOMOAIA-COTISEL1,3
1Babes-Bolyai
University, Faculty of Chemistry and Chemical Engineering, Research Centre of
Physical Chemistry, 11 Arany Janos Str., RO 400028, Cluj-Napoca, Romania
2Iuliu Hatieganu University of Medicine and Pharmacy, Department
of Orthopedic Surgery, 47 General Traian Mosoiu Str.,
RO 400132, Cluj-Napoca, Romania
3Academy of Romanian
Scientist, 3 Ilfov Str., District 5, RO 050044, Bucharest, Romania
*Corresponding author: Maria Tomoaia Cotisel, mcotisel@gmail.com
Abstract. Silymarin (SIL) is a component extracted from Silybum marianum herb and is
studied in medicine due to its protective activities on certain organs (liver,
kidney, heart, brain). The
review discusses some methods that increase silymarin bioavailability such as
development of complexes with cyclodextrins, phospholipids, liposome and
nanostructured material (hydroxyapatite-HAP). The interactions between SIL and
alpha-lipoic acid, metallic nanoparticles (gold nanoparticles-GNP, and silver
nanoparticles SNP), some carotenoids (β-carotene and lycopene) and
curcumin were debated too. Some combined treatments (e.g. SIL + curcumin)
highlighted anticancer activity against colon cancer cells (DLD-1, HCT116 and LoVo) and protective effect against chemicals toxicity.
Key words: Silymarin, complexes,
hydroxyapatite, phospholipids, metallic nanoparticles, carotenoid
DOI https://doi.org/10.56082/annalsarscibio.2022.1.146
